TAME Trial: Metformin as Anti-Aging Drug

• First FDA-recognized aging indication trial — 14 US research institutions, 6-year study
• Targets whether metformin delays onset of age-related diseases

Senolytic Therapy: D+Q

• Dasatinib + Quercetin selectively eliminates senescent cells
• Unity Biotechnology UBX1325 in Phase 2 for age-related eye disease

KIR-CAR T Cell Therapy (AACR 2026)

• Novel KIR-CAR T demonstrates safety and dose-dependent efficacy in solid tumors
• Universal (off-the-shelf) CAR-T could reduce cost from ~$500K to $50K

80+ CRISPR Clinical Trials Active

• Casgevy (Vertex/CRISPR): first approved CRISPR therapy, generating real-world evidence
• Base editing (Beam Therapeutics): precision without double-strand breaks
• In vivo LNP delivery (Intellia): durable gene knockdown — potential single-dose cures